Synthetic Study of C1–C13 Intermediate in Phoslactomycins and Leustroducsins
Phoslactomycins and leustroducsins are highly functionalized polyketides. In this paper, we report the new synthetic method for the C1-C13 fragment. This method involves a Suzuki-Miyaura coupling reaction between the C3-C7 acetylene and C8-C13 iodoolefin, followed by construction of the lactone part. The C8-C9 diol is constructed by dihydroxylation in the late stage of the synthesis.
Authors
- Narihito Ogawa (ORCID: https://orcid.org/0000-0001-6330-1108)
- Masahiro Ishijima
- Shunki Mamada
Institutions
- Meiji University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1248/cpb.c25-00714
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science