Comprehensive microbiome and metabolome analysis revealed the changes of semen microbial characteristics and metabolic phenotypes in patients with idiopathic oligoasthenozoospermia
The microbial community structure and metabolic profiles in the semen of IOA patients exhibit significant disruption. Diagnostic models constructed based on combined microbial-metabolite features demonstrate potential for effectively distinguishing disease phenotypes. The core dysregulated bacterial genera, associated metabolites, and related pathways may serve as early diagnostic biomarkers and therapeutic intervention targets.
Authors
- Peihai Zhang (ORCID: https://orcid.org/0000-0002-4836-9902)
- Ziyang Ma (ORCID: https://orcid.org/0009-0003-2661-8669)
- Shikuan Lu
- Tang K. Tang
- Meilin Wu
- Ye Dong
- Yipeng Zhao
- Zhiyu Wu
Institutions
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1741184
- Primary Topic
- Urologic and reproductive health conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu University of Traditional Chinese Medicine
- Chengdu University
- Maryland Population Research Center, University of Maryland