Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production
This study provides the first evidence that non-histone lactylation (TRIM21 K345) exacerbates inflammatory orchitis and highlights TRIM21 lactylation or CXCL9/10 as promising therapeutic targets for infection-associated male infertility.
Authors
- Yang David Dai (ORCID: https://orcid.org/0000-0002-7638-849X)
- W.T. Chen
- Zhigang Lei (ORCID: https://orcid.org/0000-0003-1156-1973)
- N Li
- Chuan Su (ORCID: https://orcid.org/0000-0002-8271-2428)
- Lei Xu (ORCID: https://orcid.org/0009-0004-1374-2211)
- Xuan Xie (ORCID: https://orcid.org/0000-0003-2475-212X)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- WB Sun
- Chuan Su
- Wei Li
- Jifeng Zhu
- Jiahao Sha
- Yalin Li
- Yihong Jiang
Institutions
- Shanghai Jiao Tong University (CN)
- Jiangsu Institute of Parasitic Diseases (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1684836
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University