Synergistic effects of levo-tetrahydropalmatine and low-dose naltrexone on nicotine conditioned place preference in mice: a dual-target strategy based on dopamine and opioid systems
These findings indicate that the combination therapy based on dual-action mechanism of l-THP and LDN, targeting both dopamine and opioid pathways, effectively attenuates nicotine-induced CPP in mice, which may offer a potential treatment for nicotine addiction. The combination enhances therapeutic efficacy within the nicotine-induced CPP paradigm and correlates with an elevation of β-endorphin levels.
Authors
- Yiran Zhao (ORCID: https://orcid.org/0000-0002-0841-967X)
- Feng Ke (ORCID: https://orcid.org/0000-0002-1906-9636)
- Li Liu (ORCID: https://orcid.org/0000-0002-4330-5694)
- Mingming Yu (ORCID: https://orcid.org/0009-0001-3665-4925)
- Zhihua Lv (ORCID: https://orcid.org/0000-0002-5505-9902)
- Sherwin K. B. Sy
- Meixing Yan
- Shan Kang
Institutions
- Qingdao University (CN)
- Universidade Estadual de Maringá (BR)
- Qingdao Women and Children's Hospital (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fphar.2026.1697258
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00