Step‐Economical Synthesis of 2,4‐Disubstituted Phthalazinones via a <i>t</i> ‐ <scp>BuONa</scp> ‐Promoted One‐Pot Reaction
ABSTRACT A t ‐BuONa‐promoted, one‐step synthesis of 2,4‐disubstituted phthalazinones from 3‐ylidenephthalides under mild reaction conditions has been developed. The reaction shows broad scope for both alkyl and aryl substituents that can be readily introduced at the N2 position. Moreover, the protocol is compatible with a broad range of substrates and facilitates late‐stage functionalization, demonstrating its general applicability in synthetic and medicinal chemistry.
Authors
- Jinfei Yang (ORCID: https://orcid.org/0000-0002-1650-1761)
- Fu‐Qiang Yu
- Xin‐Yi Yin
- Xujie Wang (ORCID: https://orcid.org/0000-0002-2043-1567)
- Junwei Wang (ORCID: https://orcid.org/0009-0002-1404-9983)
- Yan‐Rui Fan
- Pei‐Lu Song
Institutions
- Qingdao University (CN)
- Shandong University of Technology (CN)
- Shandong University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Health & Life (Taiwan) (TW)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1002/jhet.70161
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Qingdao