Disposition and effects of alpha-pyrrolidinoisohexanophenone (α-PHiP) in comparison with cocaine: an observational study
This study provides novel insights into the effects and distribution of α-PHiP across various biological matrices. α-PHiP elicited prototypical subjective effects characteristic of psychostimulants, confirming its potential for abuse. Compared to cocaine, α-PHiP produced similar subjective effects. Future research should further investigate the detection of its metabolites to improve monitoring and understanding of its pharmacokinetics.
Authors
- Emilia Marchei (ORCID: https://orcid.org/0000-0002-7158-6032)
- Alessandro Di Giorgi (ORCID: https://orcid.org/0000-0003-2997-221X)
- Soraya Martín
- Simona Pichini (ORCID: https://orcid.org/0000-0002-6347-0750)
- Esther Papaseit (ORCID: https://orcid.org/0000-0003-2620-4274)
- Silvia Graziano (ORCID: https://orcid.org/0000-0002-5609-0872)
- Olga Hladun (ORCID: https://orcid.org/0000-0002-6230-5876)
- Dolly Andrea Caicedo (ORCID: https://orcid.org/0009-0009-6523-0265)
- Martha Catalina Argote
- Mireia Ventura
- Lourdes Poyatos
- Clara Pérez-Mañá
- Georgina De la Rosa
- Giorgia Iacobone
- Magí Farré
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat Pompeu Fabra (ES)
- National Drug Addiction Center (BG)
- Federazione Medico Sportiva Italiana (IT)
- Parc de Salut (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Centre d’Investigació i Desenvolupament (ES)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fphar.2025.1728824
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00