GC-MS-based metabolic profiling of essential oils from Citrus paradisi, Lawsonia inermis, and Ruta graveolens and assessment of their acetylcholinesterase inhibitory potential

The notable AChE inhibitory activity observed in grapefruit and henna essential oils is likely attributable to their high terpenoid content. These findings suggest that selected plant-derived essential oils may represent promising natural candidates for the prevention or management of neurodegenerative disorders such as Alzheimer's disease.

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Publication Details

Journal
Frontiers in Chemistry
Published
2026-01-14
DOI
https://doi.org/10.3389/fchem.2025.1761973
Primary Topic
Cholinesterase and Neurodegenerative Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

GC-MS-based metabolic profiling of essential oils from Citrus paradisi, Lawsonia inermis, and Ruta graveolens and assessment of their acetylcholinesterase inhibitory potential

Naglaa S. Ashmawy, Rema M. Amawi
Frontiers in Chemistry
Cholinesterase and Neurodegenerative Diseases
article

GC-MS-based metabolic profiling of essential oils from Citrus paradisi, Lawsonia inermis, and Ruta graveolens and assessment of their acetylcholinesterase inhibitory potential

Naglaa S. Ashmawy, Rema M. Amawi
article en

Abstract

The notable AChE inhibitory activity observed in grapefruit and henna essential oils is likely attributable to their high terpenoid content. These findings suggest that selected plant-derived essential oils may represent promising natural candidates for the prevention or management of neurodegenerative disorders such as Alzheimer's disease.

Frontiers in ChemistryVol. 13
Ain Shams University (EG), Rochester Institute of Technology (US), Dubai Medical College (AE), Dubai Pharmacy College (AE)
Openalex Percentile: Top 87%
Cholinesterase and Neurodegenerative Diseases
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GC-MS-based metabolic profiling of essential oils from Citrus paradisi, Lawsonia inermis, and Ruta graveolens and assessment of their acetylcholinesterase inhibitory potential — Naglaa S. Ashmawy, Rema M. Amawi · Frontiers in Chemistry (2026) | TGRS Research Map | TGRS