Proteomics and acetyl-proteomics reveal the antibacterial mechanism of berberine sulfate against methicillin-resistant Staphylococcus aureus
These results indicate that berberine sulfate mediates a comprehensive stress response in MRSA through extensive alterations in protein expression and post-translational modifications. Specifically, the acetylation of SarA at K82 and the consequent impairment of its DNA-binding capacity represent a potential core mechanism by which berberine sulfate suppresses MRSA virulence and adaptability.
Authors
- S Liu
- Zunli Hu
- Junyu Xu (ORCID: https://orcid.org/0000-0002-4918-0693)
- Huiling Liu (ORCID: https://orcid.org/0000-0002-7443-6697)
- Yunxu Bian
- Jiafu Zhou
- Yewen Sun
- Chuyao Lin
- Mengying Chen
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Southern Medical University (CN)
- Academia Sinica (TW)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1732962
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shanghai Rising-Star Program
- National Key Research and Development Program of China
- Program of Shanghai Academic Research Leader
- Youth Innovation Promotion Association