Mitochondrial metabolic remodeling predicts therapeutic response to PegIFN-α in chronic hepatitis B
Immune-metabolic remodeling underlies PegIFN-α-induced functional cure in CHB. Mitochondrial profiling provides a promising framework for precision stratification and immune-based therapeutic optimization.
Authors
- Qinqin Han (ORCID: https://orcid.org/0000-0001-9042-4170)
- Chengyu Xu
- Jie Zhu (ORCID: https://orcid.org/0000-0002-1879-983X)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-2560-3927)
- Junchi Xu (ORCID: https://orcid.org/0000-0002-1447-7593)
- Xiu Han
- Ruoran Zhou
- Zutao Chen
- Mingming Liu
- Yiling Chen
- Xiangwei Wu
Institutions
- Soochow University (TW)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- The Fifth People’s Hospital of Suzhou (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1719456
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00