Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure
This study provides novel evidence that CTSD and SOD2 potently contribute to autophagy regulation in DCM with HF. These findings highlight their diagnostic potential for DCM with HF and lay a foundation for exploring targeted small-molecule therapies (e.g., QL-XII-47, tipifarnib-P2) to improve the disease's clinical management.
Authors
- Z. K. Li
- Jie Li (ORCID: https://orcid.org/0000-0002-4366-7724)
- Yuxing Wang (ORCID: https://orcid.org/0000-0003-3079-5572)
- Jiayu Ren
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcvm.2025.1692768
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00