Early detection of subclinical heart disease via nonlinear heart rate variability in a doxorubicin-induced cardiomyopathy experimental model in dogs
The finding that nonlinear HRV analysis reflected early increased sympathetic activity associated with DXR administration in dogs is an important step forward in enhancing the clinical application potential of HRV.
Authors
- Kazumi Shimada (ORCID: https://orcid.org/0000-0002-2514-695X)
- Katsuhiro Matsuura (ORCID: https://orcid.org/0000-0002-6047-2865)
- Ahmed Farag (ORCID: https://orcid.org/0000-0002-1953-4294)
- Tomohiko Yoshida (ORCID: https://orcid.org/0000-0003-4311-9311)
- Mizuki Hasegawa (ORCID: https://orcid.org/0009-0007-9579-573X)
- Yui Umemoto
- Marino Hosoki
- Ken Takahashi
- Rio Hayashi (ORCID: https://orcid.org/0009-0008-6489-0571)
- M. Sasaki
- Akari Hatanaka (ORCID: https://orcid.org/0009-0000-9505-3065)
- Ryou Tanaka
- Lina Hamabe
Institutions
- University of Florida (US)
- Juntendo University Urayasu Hospital (JP)
- Obihiro University of Agriculture and Veterinary Medicine (JP)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fvets.2025.1725439
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00