Differential motor signatures in isolated and narcolepsy-related REM sleep behaviour disorder: a preliminary study
iRBD and NT1-RBD exhibit qualitatively distinct REM motor phenotypes: upper-body-dominant, complex/scenic behaviours in iRBD versus elementary, predominantly bilateral lower-limb behaviours with notable trunk recruitment in NT1-RBD, supported by large effect sizes and convergent robustness checks. These findings motivate mechanistic studies of hypothalamic-brainstem-cortical integration in REM and suggest that semiological profiling may aid stratification in prodromal neurodegeneration.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Peter J. Goadsby (ORCID: https://orcid.org/0000-0003-3260-5904)
- Danielle Wasserman
- Iain Duncan (ORCID: https://orcid.org/0000-0002-8473-9755)
- Ivana Rosenzweig (ORCID: https://orcid.org/0000-0003-2152-9694)
- Panagis Drakatos (ORCID: https://orcid.org/0000-0002-8298-7878)
- Huiling Tan
- Valentina Gnoni
- Luigi Ferini-Strambi
- David O’Regan
- Keyoumars Ashkan
- K. Ray Chaudhuri
- Liborio Parrino
Institutions
- Allen Institute for Brain Science (US)
- Vita-Salute San Raffaele University (IT)
- King's College London (GB)
- University of Oxford (GB)
- MRC Brain Network Dynamics Unit (GB)
- King's College Hospital NHS Foundation Trust (GB)
- University Hospitals Parma Medical Center (US)
- St. Thomas Hospital (CA)
- Mayo Clinic in Arizona (US)
- NIHR Wellcome Trust Southampton Clinical Research Facility (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fneur.2025.1749306
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- King's College London