Efficacy and Safety of VMAT2 Inhibitors in the Treatment of Huntington Disease

In patients with HD, treatment with VMAT2is improved chorea (UHDRS-TMC and CGI-C), with no significant changes in adverse effects or depressive symptoms. These findings indicate that VMAT2is may be a promising and safe treatment option for the disease.

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Publication Details

Journal
Neurology Clinical Practice
Published
2026-01-13
DOI
https://doi.org/10.1212/cpj.0000000000200578
Primary Topic
Genetic Neurodegenerative Diseases
Type
article
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article

Efficacy and Safety of VMAT2 Inhibitors in the Treatment of Huntington Disease

Elder Machado Leite, Golding Rodrigues, João Eduardo Silva Lima, Armando Leão Lages et al.
Neurology Clinical Practice
Genetic Neurodegenerative Diseases
article

Efficacy and Safety of VMAT2 Inhibitors in the Treatment of Huntington Disease

Elder Machado Leite, Golding Rodrigues, João Eduardo Silva Lima, Armando Leão Lages, Adelson Barroso Junior, José Arnaldo Cavalcanti Amorim, José Fernando Barbosa Moura
article en

Abstract

In patients with HD, treatment with VMAT2is improved chorea (UHDRS-TMC and CGI-C), with no significant changes in adverse effects or depressive symptoms. These findings indicate that VMAT2is may be a promising and safe treatment option for the disease.

Neurology Clinical PracticeVol. 16(2)
Universidade de Pernambuco (BR), Universidade Federal de Alagoas (BR)
Good health and well-being
Openalex Percentile: Top 89%
Genetic Neurodegenerative Diseases
DOIOpen Access PDFOpenAlex
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