Andrological Outcomes in Boys Undergoing Testicular Tissue Extraction Prior to Gonadotoxic Treatment: Evolution During Peripuberty and Young Adulthood

Males undergoing TTE prior to gonadotoxic therapy frequently develop persistent Sertoli cell dysfunction, with limited fertility potential in many cases. These findings underscore the importance of systematic, long-term andrological surveillance and personalised fertility counselling in this high-risk population.

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Publication Details

Journal
Clinical Endocrinology
Published
2026-01-14
DOI
https://doi.org/10.1111/cen.70073
Primary Topic
Sperm and Testicular Function
Type
article
Field-Weighted Citation Impact
0.00
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Andrological Outcomes in Boys Undergoing Testicular Tissue Extraction Prior to Gonadotoxic Treatment: Evolution During Peripuberty and Young Adulthood

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Andrological Outcomes in Boys Undergoing Testicular Tissue Extraction Prior to Gonadotoxic Treatment: Evolution During Peripuberty and Young Adulthood

Iva Gueorguieva, Bérengère Ducrocq, Arthur Lauriot Dit Prévost, P. Pigny, Hamza Benderradji, E. Martín, C. Leroy, Christine Lefevre, François Marcelli, Anne‐Sophie Defachelles, Laura Keller
article en

Abstract

Males undergoing TTE prior to gonadotoxic therapy frequently develop persistent Sertoli cell dysfunction, with limited fertility potential in many cases. These findings underscore the importance of systematic, long-term andrological surveillance and personalised fertility counselling in this high-risk population.

Clinical Endocrinology
Inserm (FR), Université de Lille (FR), Centre Hospitalier Universitaire de Lille (FR), Lille’s Cardiology Hospital (FR), Centre de Recherche Jean Pierre Aubert (FR), Centre Oscar Lambret (FR)
Openalex Percentile: Top 89%
Sperm and Testicular Function
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