Autonomic small fiber involvement in painful long COVID: a histological and clinical study
These findings provide histological evidence that autonomic small fiber damage is a prominent and measurable feature of painful long COVID syndrome. Importantly, this pathology was also observed in patients with preserved IENFD, indicating that autonomic involvement may occur independently of somatic small fiber loss.
Authors
- Caterina Leone (ORCID: https://orcid.org/0000-0002-8828-361X)
- Daniel Litewczuk
- Andrea Truini (ORCID: https://orcid.org/0000-0002-2630-7647)
- P. Falco
- Eleonora Galosi (ORCID: https://orcid.org/0000-0002-4464-9982)
- G. Di Stefano
- Enrico Evangelisti
- Lars Arendt-Nielsen
Institutions
- Steno Diabetes Centers (DK)
- Aalborg University Hospital (DK)
- Sapienza University of Rome (IT)
- Aalborg University (DK)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fnhum.2025.1719705
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Danmarks Grundforskningsfond
- Novo Nordisk
- Novo Nordisk Fonden