Palladium-catalyzed Cyclization of 5-(o-Aminoaryl) 1,2,3-Triazoles with Isocyanides to Construct Triazolo [1,5-c]Quinazolines

Abstract A series of triazoloquinazoline derivatives were synthesized by insertion cyclization of 5-(o-aminoaryl) 1,2,3-triazoles with isocyanides under palladium catalysis. This method features the construction of tricyclic-fused 1,2,3-triazoles involving two C–N bond formations in one simple manipulation. The system is suitable for a variety of 1,2,3-triazoles and isocyanides with good functional group compatibility, and even for other types of nitrogen-containing heterocyclic compounds such as 1,2,4-triazole, pyrazole, tetrazole, imidazole, and indole.