Complement-secreting CAFs are associated with better prognosis in pancreatic cancer: single-cell multiomics
Our study demonstrates that csCAFs may represent an early-stage iCAF subtype and suggests a promising strategy for reprogramming iCAFs into csCAFs.
Authors
- Jacquelyn W. Zimmerman (ORCID: https://orcid.org/0000-0002-7775-2943)
- Yongsu Ma
- J Zhang
- Pengfei Wu (ORCID: https://orcid.org/0000-0003-2152-8165)
- Jin He (ORCID: https://orcid.org/0000-0001-8038-9260)
- Qingfeng C Zhu
- Kai Chen
- Robert A Anders
- Liling Huang
- Heng-Chung Kung
- Bohan Yang
- Xiaodong Tian
Institutions
- Bloomberg (United States) (US)
- Johns Hopkins University (US)
- Peking University (CN)
- Johns Hopkins Medicine (US)
- China-Japan Friendship Hospital (CN)
- Sidney Kimmel Cancer Center (US)
- Peking University First Hospital (CN)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Gut
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1136/gutjnl-2025-335683
- Citations
- 1
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 24.43