Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma

This study provides a comprehensive characterization of the MEX3 family in glioma, demonstrating their dysregulation, prognostic relevance, immune associations, and functional contributions to malignant phenotypes. Among them, MEX3D emerges as a particularly promising prognostic biomarker. These findings establish a foundation for future mechanistic and translational studies exploring MEX3 family members as potential biomarkers or therapeutic targets in glioma.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-14
DOI
https://doi.org/10.3389/fimmu.2025.1654036
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma

Xuezhong Zhang, Hui Shang, Tingting Chu, Kaihui Sha
Frontiers in Immunology
Glioma Diagnosis and Treatment
article

Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma

Xuezhong Zhang, Hui Shang, Tingting Chu, Kaihui Sha
article en

Abstract

This study provides a comprehensive characterization of the MEX3 family in glioma, demonstrating their dysregulation, prognostic relevance, immune associations, and functional contributions to malignant phenotypes. Among them, MEX3D emerges as a particularly promising prognostic biomarker. These findings establish a foundation for future mechanistic and translational studies exploring MEX3 family members as potential biomarkers or therapeutic targets in glioma.

Frontiers in ImmunologyVol. 16
Binzhou Medical University (CN), Shandong University of Aeronautics (CN), Wenzhou Medical University (CN), Shanxi Jincheng Anthracite Mining Group (China) (CN), Central Hospital of Zibo (CN), Dongyang People's Hospital (CN)
Openalex Percentile: Top 89%
Glioma Diagnosis and Treatment
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