Electroacupuncture alleviates Parkinson’s disease by targeting HDAC/SIRT-mediated deacetylation of 14-3-3
Electroacupuncture ameliorates behavioral and neuropathological phenotypes in a PD mouse model by restoring deacetylase expression and normalizing protein acetylation, particularly of 14-3-3. Our results underscore the therapeutic potential of EA and highlight acetylation modulation as a promising strategy for PD treatment.
Authors
- Zhaoqin Wang (ORCID: https://orcid.org/0000-0002-3440-2230)
- G Li
- Handan Zheng (ORCID: https://orcid.org/0000-0002-8640-9194)
- Yiyi Chen (ORCID: https://orcid.org/0000-0002-5363-8898)
- Lu-lu Cao
- Huan-Gan Wu
- Lin Shen
- Ling-Jie Li
- Yu Qiao
- Lu-Yi Wu
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Research Center for Acupuncture and Meridians (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fnagi.2025.1719326
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China