Epithelial extracellular vesicles induce inflammation and neutrophil activation in the Pseudomonas aeruginosa infected cystic fibrosis bronchial epithelium
EVs from the PA-infected CF bronchial epithelium seem to facilitate an autocrine and paracrine pro-inflammatory response that is not attenuated by ETI treatment, suggesting a novel contribution of EVs to the chronic inflammatory phenotype observed in the PA-infected CF lung.
Authors
- Jarrod W. Barnes (ORCID: https://orcid.org/0000-0002-1027-6591)
- Meghan June Hirsch (ORCID: https://orcid.org/0000-0001-6946-7491)
- Kristopher R. Genschmer (ORCID: https://orcid.org/0000-0002-1836-9522)
- Patrick Henry Howze
- L. Jones (ORCID: https://orcid.org/0000-0003-0900-9792)
- C Margaroli
- Angela N. Morales
- Hannah J. McIntire-Ray
- Stefanie Krick
- Kuen-You Tsai
Institutions
- University of Alabama at Birmingham (US)
- Pulmonary and Allergy Associates (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1659951
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute