DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy
These findings suggest DX243 as a novel neuroprotective drug, that specifically protects auditory fibers contributing to the coding of the temporal envelope and detection of tones in masking noise, tasks of our auditory senses, both of which, if they fail, lead to age-related speech-in-noise comprehension deficits.
Authors
- Csaba Harasztosi (ORCID: https://orcid.org/0000-0002-9218-8690)
- Lukas Rüttiger
- Stefan Fink (ORCID: https://orcid.org/0000-0002-7938-9869)
- Lijun Xie (ORCID: https://orcid.org/0000-0002-3618-8549)
- Marlies Knipper
- Stephane Silvente
- Nicolas Caron
- Pierre Attali
- Wibke Singer
Institutions
- Tongji University (CN)
- TiGenix (Spain) (ES)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fphar.2025.1673189
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung
- Fonds Wetenschappelijk Onderzoek
- China Scholarship Council