Nell-1 regulates fibrocartilage stem cells and alleviates temporomandibular joint osteoarthritis progression by inhibiting hedgehog pathway
Nell-1 leads to improved chondrogenic capacity of FCSCs in TMJOA and demonstrated an inhibitory effect on Hh signal transduction while concurrently facilitating the process of cartilage remodeling. Collectively, Nell-1 may be a promising drug candidate for the treatment of TMJOA.
Authors
- Shiyu Hu
- Na Wu (ORCID: https://orcid.org/0000-0002-8450-4091)
- Jiejun Shi
- Cunyi Wang
- Wen Li
Institutions
- Zhejiang Cancer Hospital (CN)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1186/s13018-025-06461-0
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China