Protein kinase C epsilon deletion in AgRP neurons modulates hypothalamic glucose sensing and improves glucose tolerance in mice
Ablation of PKCε in AgRP neurons improves glucose homeostasis in fat-fed mice. This appears to be mediated through glucose sensing mechanisms, potentially reducing sympathetic outflow from the hypothalamus to tissues such as adipose, reducing lipolysis to indirectly lower hepatic glucose production.
Authors
- Anthony S. Don (ORCID: https://orcid.org/0000-0003-1655-1184)
- H HERZOG
- Lewin Small (ORCID: https://orcid.org/0000-0002-9767-9464)
- Nicola J. Lee (ORCID: https://orcid.org/0000-0001-7766-6095)
- Amanda E. Brandon (ORCID: https://orcid.org/0000-0002-4996-7189)
- Zhongmin Gao
- Chi Kin Ip (ORCID: https://orcid.org/0000-0002-0464-4706)
- Oana C. Marian (ORCID: https://orcid.org/0000-0001-5629-7884)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-9494-3699)
- C. Yan (ORCID: https://orcid.org/0009-0008-4766-6375)
- Carsten Schmitz-Peiffer
- Alex Perez
- Yan-Chuan Shi
Institutions
- The University of Sydney (AU)
- Garvan Institute of Medical Research (AU)
- St Vincent's Clinic (AU)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1016/j.molmet.2026.102320
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00