Actinidia chinensis Planch Root extracts trigger ferroptosis in colorectal cancer via the p53/SLC7A11/GPX4 axis
Our findings demonstrate that acRoots exerts potent anti-Colorectal cancer effects by inhibiting malignant phenotypes and inducing ferroptosis. This ferroptosis is mediated, at least in part, through the p53-dependent downregulation of the SLC7A11/GPX4 axis. These results position acRoots as a promising therapeutic candidate and a novel natural ferroptosis inducer for Colorectal cancer treatment, warranting further clinical investigation.
Authors
- Wei Cui (ORCID: https://orcid.org/0000-0002-8177-0538)
- R.S. Chen
- Jianan Wang (ORCID: https://orcid.org/0000-0003-1384-3966)
- Hui Shao (ORCID: https://orcid.org/0000-0002-3790-4754)
- Hangxuan Wang
- Chenyang Ma
- Zisheng Cheng
- Qing Xia
- Jun Lu
- Shiwei Duan
- Kaijie Qiu
Institutions
- Target (United States) (US)
- Ningbo Medical Center Lihuili Hospital (CN)
- Hangzhou City University
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fphar.2026.1724983
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00