Regulation of Primary Hemostasis by Peptides with Neuroprotective Effect

This review summarizes the current understanding of the antiplatelet effects of glyproline peptides (glyprolins) based on literature data and our own experimental studies. The unique properties of these bioregulators are analyzed, allowing them, along with the main neuroprotective effect in the body, to influence the processes of vascular-platelet hemostasis, which are the main focus of our review. The results of our own studies on PGP, PG, cGP, PGP with the addition of arginine, lysine or leucine, Semax, Selank, KKRRPGP, ACTH(6-9)PGP effects on platelet aggregation activity in normal and metabolic disorders in the body are presented. Generalized data on the properties of the considered peptides led us to conclude that glyprolins have the neuroprotective and antiplatelet effect on the body and to propose their use in clinical practice for the prevention and complex therapy of metabolic disorders.