Acquired Progressive Kinking of the Hair: A Narrative Review of the Androgen‐Dependent Phenotype

Acquired progressive kinking of the hair (APKH) is an underrecognized hair disorder characterized by a gradual change in hair texture, often manifesting as increased curliness, frizziness, and darkening of the shafts. While various systemic triggers and congenital conditions can induce similar phenotypes, a subset of cases-particularly those involving the frontal and temporal scalp in young males-appears to be linked to androgen-mediated mechanisms. This narrative review focuses on the androgen-dependent phenotype of APKH, integrating clinical, trichoscopic, and histopathological findings and presenting a representative case. We also propose a conceptual framework for distinguishing between androgen-dependent and non-androgen-dependent subtypes. A detailed analysis of all published cases meeting criteria for androgen-sensitive APKH is provided, highlighting patterns of progression, diagnostic clues, and therapeutic implications. Recognizing this presentation as a potential early manifestation of androgenetic alopecia may inform clinical decisions and prompt timely intervention.

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Publication Details

Journal
International Journal of Dermatology
Published
2026-01-14
DOI
https://doi.org/10.1111/ijd.70281
Primary Topic
Hair Growth and Disorders
Type
article
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article

Acquired Progressive Kinking of the Hair: A Narrative Review of the Androgen‐Dependent Phenotype

Carlos Barrera‐Ochoa, Fernanda Martínez‐Saharopulos, Antonella Tosti, Vanessa Vargas‐Vega et al.
International Journal of Dermatology
Hair Growth and Disorders
article

Acquired Progressive Kinking of the Hair: A Narrative Review of the Androgen‐Dependent Phenotype

Carlos Barrera‐Ochoa, Fernanda Martínez‐Saharopulos, Antonella Tosti, Vanessa Vargas‐Vega, Daniel Asz‐Sigall, Eduardo Corona‐Rodarte, Marla Olivas‐Altamirano
article en

Abstract

Acquired progressive kinking of the hair (APKH) is an underrecognized hair disorder characterized by a gradual change in hair texture, often manifesting as increased curliness, frizziness, and darkening of the shafts. While various systemic triggers and congenital conditions can induce similar phenotypes, a subset of cases-particularly those involving the frontal and temporal scalp in young males-appears to be linked to androgen-mediated mechanisms. This narrative review focuses on the androgen-dependent phenotype of APKH, integrating clinical, trichoscopic, and histopathological findings and presenting a representative case. We also propose a conceptual framework for distinguishing between androgen-dependent and non-androgen-dependent subtypes. A detailed analysis of all published cases meeting criteria for androgen-sensitive APKH is provided, highlighting patterns of progression, diagnostic clues, and therapeutic implications. Recognizing this presentation as a potential early manifestation of androgenetic alopecia may inform clinical decisions and prompt timely intervention.

International Journal of Dermatology
Universidad Autónoma de Guadalajara (MX), University of Miami (US), Secretaría de Salud de Jalisco (MX), Hospital Médica Sur (MX), Hospital General Dr. Manuel Gea Gonzalez (MX), MSD (Mexico) (MX), Hospital Civil de Guadalajara (MX)
Openalex Percentile: Top 89%
Hair Growth and Disorders
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