Patterns, risk factors and management of CD19-directed chimeric antigen receptor T-cell therapy failure in CNS lymphoma
This study identifies novel radiological risk factors for CD19-CAR failure in CNSL, namely pCE and LMD. Outcome in this setting is unfavorable and encouraging salvage treatments warrant prospective evaluation.
Authors
- Chirayu G. Patel (ORCID: https://orcid.org/0000-0002-6015-6184)
- Jeffrey A. Barnes (ORCID: https://orcid.org/0000-0002-4867-1909)
- Marcela V. Maus (ORCID: https://orcid.org/0000-0002-7578-0393)
- Ephraim P. Hochberg (ORCID: https://orcid.org/0000-0001-9050-7208)
- Leon D. Kaulen (ORCID: https://orcid.org/0000-0002-5937-3376)
- Bryan D. Choi (ORCID: https://orcid.org/0000-0002-5090-2470)
- W. Wick
- Jacob D. Soumerai (ORCID: https://orcid.org/0000-0002-3062-6819)
- Ganesh M. Shankar
- Jeremy Abramson
- Jorg Dietrich
- Matthew J. Frigault
- Philipp Karschnia
- Yi-Bin Chen
- Sofia Doubrovinskaia
- P. Connor Johnson
- J. Erika Haydu
Institutions
- Harvard University (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Massachusetts General Hospital (US)
- Universitätsklinikum Erlangen (DE)
- Center for Neuro-Oncology (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1186/s13045-025-01761-8
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Krebsforschungszentrum