Polymyxin-resistant hypervirulent Klebsiella pneumoniae clinical isolates from a tertiary hospital in China: molecular mechanisms, antimicrobial susceptibility, and virulent phenotypes
Our findings indicated a relatively low prevalence of plasmid-mediated mobile polymyxin resistance genes among PoRKP isolates, whereas the upregulation of the two-component systems (particularly phoPQ) played a more prominent role in mediating polymyxin resistance.
Authors
- J. Stephen Yan (ORCID: https://orcid.org/0000-0002-8485-354X)
- Yuzhou He (ORCID: https://orcid.org/0000-0002-9441-4188)
- Xinyu Zhu
- Mengyuan Chen
- Qiang Wang
- Tingjian Zou
- Xiyun Lai
- Xiaofang Tang
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fmicb.2025.1705471
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Key Research and Development Program of China