The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects
RORα, RORβ, and RORγ function as complementary regulators of bone homeostasis and represent compelling targets for precision therapeutics against OP and related skeletal disorders. Future research should prioritize defining spatiotemporal regulation within bone microenvironments, quantifying immune-mediated RORγt signaling, and optimizing chronopharmacological strategies to enable time-synchronized, subtype-selective interventions.
Authors
- Liangsheng Wei
- X Zhang
- Qiaoning Yue
- Mingyao Lu
- Xiaoyan Liang (ORCID: https://orcid.org/0009-0009-2783-851X)
- Dayong Yang
- Zidan Zhang
- Shaogang Miao
- Yi Zhang
Institutions
- Zunyi Medical University (CN)
- Kunming Medical University (CN)
- Tibet Autonomous Region People's Hospital (CN)
- Sixth Affiliated Hospital of Kunming Medical University (CN)
- Dali University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1080/07853890.2026.2615534
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 24.43