Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer’s disease
Our findings highlight two distinct genetic-dose dependent backgrounds: "vulnerable" (<50% inflammatory PRS) and "resilient" (≥50% inflammatory PRS), and support a Genome-Internal Environment (G×IE) interaction model, linking peripheral inflammation to AD risk.
Authors
- C.H. Doan
- R. Au
- Habbiburr Rehman (ORCID: https://orcid.org/0000-0003-1762-3573)
- Wei Qiu (ORCID: https://orcid.org/0009-0001-9985-8343)
- Thor D. Stein
- Qiushan Tao
- Jesse Mez
- Xiaoling Zhang
- Lindsay A. Farrer
- Jinghan Huang
Institutions
- Boston University (US)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.nbd.2026.107257
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00