Detection of clonal hematopoiesis of indeterminate potential via genome or exome sequencing underestimates disease associations
Epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome sequencing versus deep targeted sequencing.
Authors
- Caitlyn Vlasschaert (ORCID: https://orcid.org/0009-0003-8466-7602)
- K. Amancherla
- Robert W. Corty (ORCID: https://orcid.org/0000-0002-6787-9051)
- Michael Robert Savona (ORCID: https://orcid.org/0000-0003-3763-5504)
- Leo Luo
- Yash Pershad
- Alexander G. Bick
- J. Brett Heimlich
- Taralynn Mack
Institutions
- University of Washington (US)
- Queen's University (CA)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1172/jci198861
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00