Integrating cuproptosis- and ferroptosis-related gene signatures to predict prognosis, immunotherapy response, and drug sensitivity in patients with skin cutaneous melanoma
IFNG, PTPN6, SLC38A1, and SOCS1 may serve as potential biomarkers of poor prognosis in SKCM patients. These genes demonstrate predictive value for immunotherapy response and drug sensitivity, particularly indicating susceptibility to selumetinib treatment, and therefore show substantial potential for clinical translation.
Authors
- Hua Dong (ORCID: https://orcid.org/0000-0002-8235-726X)
- Xiang Li (ORCID: https://orcid.org/0000-0002-5942-7282)
- Zhaofeng Ding
- Ying Huang
- Wei Wang
- Jie Shen
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1742614
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00