Incidence and outcomes of major bleeding among first-time oral factor Xa inhibitor users: multinational observational cohort studies
Results of this large-scale study indicate that the incidence of major bleeding remains elevated during the first 3 years after initiating FXai treatment and that these bleeding events seemed to be associated with significant mortality.
Authors
- Ali Canbay (ORCID: https://orcid.org/0000-0001-6069-7899)
- Robert C. Welsh (ORCID: https://orcid.org/0000-0003-2613-9142)
- George Godfrey (ORCID: https://orcid.org/0000-0003-1891-1817)
- W. Beekman
- Eddy Lang (ORCID: https://orcid.org/0000-0003-0850-4337)
- Elisabeth Smits (ORCID: https://orcid.org/0000-0003-1882-4748)
- Arsh Randhawa
- Chatree Chai‐Adisaksopha (ORCID: https://orcid.org/0000-0001-7209-9722)
- Craig I Coleman (ORCID: https://orcid.org/0000-0003-4868-7158)
- Jil Billy Mamza (ORCID: https://orcid.org/0000-0001-6240-7525)
- Beatriz Palacios (ORCID: https://orcid.org/0009-0002-0089-2291)
- Jenneke Leentjens (ORCID: https://orcid.org/0000-0003-3356-3910)
- He Gao (ORCID: https://orcid.org/0000-0001-7764-198X)
- Douglas C. Dover (ORCID: https://orcid.org/0000-0002-2634-857X)
- Felix Scherg
- Ruiqi Zhang
- Juan Arenillas
- Alexander T. Cohen
- Satarupa Choudhuri
- Chaozer Er
Institutions
- University of Connecticut (US)
- Radboud University Nijmegen (NL)
- University of Alberta (CA)
- University of Calgary (CA)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Radboud University Medical Center (NL)
- Northern Health and Social Care Trust (GB)
- AstraZeneca (France) (FR)
- Canadian VIGOUR Centre (CA)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- AstraZeneca (Netherlands) (NL)
- Pharmo Institute (NL)
- AstraZeneca (Switzerland) (CH)
- AstraZeneca (Italy) (IT)
- Woodlands Health Campus (SG)
- AstraZeneca (Spain) (ES)
- AstraZeneca (Canada) (CA)
- Hospital Clínico Universitario de Valladolid (ES)
- AstraZeneca (Germany) (DE)
- Chiang Mai University (TH)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1016/j.rpth.2026.103351
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00