Incidence and outcomes of major bleeding among first-time oral factor Xa inhibitor users: multinational observational cohort studies

Results of this large-scale study indicate that the incidence of major bleeding remains elevated during the first 3 years after initiating FXai treatment and that these bleeding events seemed to be associated with significant mortality.

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Publication Details

Journal
Research and Practice in Thrombosis and Haemostasis
Published
2026-01-14
DOI
https://doi.org/10.1016/j.rpth.2026.103351
Primary Topic
Blood Coagulation and Thrombosis Mechanisms
Type
article
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article

Incidence and outcomes of major bleeding among first-time oral factor Xa inhibitor users: multinational observational cohort studies

Ali Canbay, Robert C. Welsh, George Godfrey, W. Beekman et al.
Research and Practice in Thrombosis and Haemostasis
Blood Coagulation and Thrombosis Mechanisms
article

Incidence and outcomes of major bleeding among first-time oral factor Xa inhibitor users: multinational observational cohort studies

Ali Canbay, Robert C. Welsh, George Godfrey, W. Beekman, Eddy Lang, Elisabeth Smits, Arsh Randhawa, Chatree Chai‐Adisaksopha, Craig I Coleman, Jil Billy Mamza, Beatriz Palacios, Jenneke Leentjens, He Gao, Douglas C. Dover, Felix Scherg, Ruiqi Zhang, Juan Arenillas, Alexander T. Cohen, Satarupa Choudhuri, Chaozer Er
article en

Abstract

Results of this large-scale study indicate that the incidence of major bleeding remains elevated during the first 3 years after initiating FXai treatment and that these bleeding events seemed to be associated with significant mortality.

Research and Practice in Thrombosis and HaemostasisVol. 10(2)
University of Connecticut (US), Radboud University Nijmegen (NL), University of Alberta (CA), University of Calgary (CA), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Radboud University Medical Center (NL), Northern Health and Social Care Trust (GB), AstraZeneca (France) (FR), Canadian VIGOUR Centre (CA), Universitätsklinikum Knappschaftskrankenhaus Bochum (DE), AstraZeneca (Netherlands) (NL), Pharmo Institute (NL), AstraZeneca (Switzerland) (CH), AstraZeneca (Italy) (IT), Woodlands Health Campus (SG), AstraZeneca (Spain) (ES), AstraZeneca (Canada) (CA), Hospital Clínico Universitario de Valladolid (ES), AstraZeneca (Germany) (DE), Chiang Mai University (TH)
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Blood Coagulation and Thrombosis Mechanisms
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