Affiliative behaviours regulate allostasis development and shape biobehavioural trajectories in horses
Social interactions shape both the physiological and behavioural development of offspring, and poor care/early caregiver loss is known to promote adverse outcomes during infancy in both animals and humans. How affiliative behaviours impact the future development of offspring remains an open question. Here, we used Equus caballus (domestic horse) as a model to investigate this question. By coupling magnetic resonance imaging, longitudinal biobehavioural assessments and advanced multivariate statistical modelling, we found that prolonged maternal presence during infancy promotes the maturation of brain regions involved in both social behaviour (anterior cingulate cortex and retrosplenial cortex) and physiological regulation (hypothalamus and amygdala). Additionally, offspring benefiting from a prolonged maternal presence showed higher default mode network connectivity, improved social competences and feeding behaviours, and higher concentrations of circulating lipids (triglyceride and cholesterol). The findings of the present study underscore the salient role of social interactions in the development of allostatic regulation in offspring.
Authors
- C. Poupon
- Hugues Dardente (ORCID: https://orcid.org/0000-0001-7209-5940)
- Isabelle Lévy
- P Barrière
- Hans Adriaensen (ORCID: https://orcid.org/0000-0002-7239-9095)
- Mathilde Valenchon (ORCID: https://orcid.org/0000-0003-0226-8433)
- Amandine Gesbert
- Joëlle Dupont (ORCID: https://orcid.org/0000-0002-8046-7705)
- Matthieu Keller
- Yvan Gaude
- Gaëlle Lefort
- Léa Lansade (ORCID: https://orcid.org/0000-0002-5462-7138)
- Camille Ducluzeau
- Frédéric Elleboudt
- Ivy USZYNSKI
- Anne-Lyse Lainé
- Fabrice Reigner
- David André Barrière
Institutions
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- AgroParisTech (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Département Santé Animale (FR)
- Physiologie de la Reproduction et des Comportements (FR)
- CEA Paris-Saclay (FR)
- Services déconcentrés d'appui à la recherche Val de Loire (FR)
- Servier (France) (FR)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1038/s41467-025-66729-1
- Primary Topic
- Veterinary Equine Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- European Regional Development Fund
- H2020 Marie Skłodowska-Curie Actions