Disruptive effects of phthalates and their substitutes on adrenal steroidogenesis
This in vitro study provides novel evidence on phthalate- and substitute-induced endocrine disruption of adrenal steroidogenesis, favouring mineralo- and glucocorticoid secretion, potentially linking these substances to secondary hypertension. Notably, emerging substitute substances (e.g., DEHT, DINCH) showed similar effects of adrenal disruption, compared to classical phthalates.
Authors
- Benedikt Pötzl
- Sabine Kendl
- Ulrich Dischinger (ORCID: https://orcid.org/0009-0008-4885-9355)
- Max Kurlbaum (ORCID: https://orcid.org/0000-0002-8438-2127)
- Lydia Kürzinger
- Simon Kloock (ORCID: https://orcid.org/0009-0005-4610-0888)
- Sabine Herterich
- Martin Fassnacht
Institutions
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fendo.2025.1734184
- Citations
- 1
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 31.09