Transcriptome changes in overweight neutered female dogs undergoing a weight loss program with or without Spirulina (Arthrospira platensis) supplementation

This study could be considered a starting point to explore the mechanisms behind weight loss and Spirulina supplementation in overweight/obese neutered female dogs. Iron homeostasis is a sort of red thread in our evidence, underlining the importance of the fine-tuning of this micronutrient in obesity. Despite the possible masking effect of the diet, meaningful insights about Spirulina supplementation were disclosed, suggesting its possible beneficial effects. Nevertheless, wider investigations are needed, increasing the number of subjects, comparing other tissues and taking into consideration specific cell populations.