Salidroside-Loaded, TMTP1-Modified CSC-Exosomes Reprogram the PI3K/AKT/mTOR Axis to Overcome PD-1 Resistance in Breast Cancer
Salidroside@T-exo reverses PD-1 blockade resistance by simultaneously inhibiting PI3K/AKT/mTOR signaling in T cells and eradicating breast CSCs, offering a clinically translatable strategy for refractory breast cancer immunotherapy.
Authors
- Qiang Xie
- Ligong Zhang
- Jun Qian
- Xin Jin
- Faxiang Yin
Institutions
- Bengbu Medical College (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2026-01-14
- DOI
- https://doi.org/10.4143/crt.2025.849
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Provincial Department of Education