Dynamic changes in prognostic nutritional index and systemic immune-inflammation index predict survival following debulking surgery in ovarian cancer

Postoperative PNI and preoperative SII provide complementary and independent prognostic information in patients undergoing primary debulking surgery for ovarian cancer. ΔPNI reflects acute immunonutritional stress but does not independently predict survival. Given their accessibility and modifiability, these indices may support perioperative risk stratification and represent potential targets for future interventional studies.