Vertebral metastasis with spinal cord compression as the first manifestation of hepatocellular carcinoma: a case report

This case highlights the variability in hepatocellular carcinoma presentations and underscores the need for heightened clinical vigilance in patients presenting with unexplained bone or neurological symptoms, even in the absence of overt hepatic signs. Skeletal metastases are rare in this tumor compared with other cancers. The diagnosis can be even more challenging when bone metastases are the predominant initial manifestation, particularly when neurological complications emerge early in the course of disease.

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Publication Details

Journal
Journal of Medical Case Reports
Published
2026-01-14
DOI
https://doi.org/10.1186/s13256-025-05758-2
Primary Topic
Management of metastatic bone disease
Type
article
Field-Weighted Citation Impact
0.00
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article

Vertebral metastasis with spinal cord compression as the first manifestation of hepatocellular carcinoma: a case report

Yacoub Haythem, Dabbebi Habiba, Hassine Hajer, Khemiri Wafa et al.
Journal of Medical Case Reports
Management of metastatic bone disease
article

Vertebral metastasis with spinal cord compression as the first manifestation of hepatocellular carcinoma: a case report

Yacoub Haythem, Dabbebi Habiba, Hassine Hajer, Khemiri Wafa, Kchir Hela, Cherif Douha, Maamouri Nadia, Gnichi Asma
article en

Abstract

This case highlights the variability in hepatocellular carcinoma presentations and underscores the need for heightened clinical vigilance in patients presenting with unexplained bone or neurological symptoms, even in the absence of overt hepatic signs. Skeletal metastases are rare in this tumor compared with other cancers. The diagnosis can be even more challenging when bone metastases are the predominant initial manifestation, particularly when neurological complications emerge early in the course of disease.

Journal of Medical Case ReportsVol. 20(1)
Hôpital La Rabta (TN)
Good health and well-being
Openalex Percentile: Top 89%
Management of metastatic bone disease
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