RAP1A Variant rs7525578 Modifies Glycemic Response to Metformin But Not to Pioglitazone or Gliclazide in the UK Biobank
The RAP1A variant rs7525578 is associated with modestly higher HbA1c among men treated with metformin, but not with pioglitazone or gliclazide. This drug-specific pharmacogenetic association mirrors mechanistic data in mice, supporting a role for Rap1 signaling in metformin action and highlighting pathway-based approaches to T2D pharmacogenetics.
Authors
- Peter H. Rheinstein (ORCID: https://orcid.org/0000-0002-4608-1665)
- Steven Lehrer
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical Neuropharmacology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1097/wnf.0000000000000659
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00