Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review
This review systematically integrates existing popPK models of imipenem, highlighting renal function and BW as key covariates. This study provides valuable insights for individualized dosing while identifying critical research gaps, particularly the need for external validation and focused studies in special populations.
Authors
- Jie Zhu (ORCID: https://orcid.org/0000-0002-1879-983X)
- Yuan Wang (ORCID: https://orcid.org/0000-0002-7355-9505)
- Ji Xu (ORCID: https://orcid.org/0000-0001-6674-9178)
- Gang Liang
- Yuhua Zhao
- Ping Zhang
- Zhenwei Yu
Institutions
- Qingdao University (CN)
- Sir Run Run Shaw Hospital (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Zhejiang Pharmaceutical College (CN)
- Taian City Central Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fphar.2025.1738055
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00