Interpretable machine learning models for beta thalassemia prediction: an explainable AI approach for smart healthcare 5.0

Furthermore ensuring the models transparency and interpretability, the proposed method integrates SHapley Ad-ditive exPlanations (SHAP) and Local Interpretable Model-Agnostic Explanations (LIME), enabling both global and local interpretability of model predictions. SHAP gives us insight into important features at the global level, while LIME explains individual predictions, making the model's decisions more comprehensible for clinical applications.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-01-14
DOI
https://doi.org/10.3389/fmed.2025.1688645
Primary Topic
Hemoglobinopathies and Related Disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Interpretable machine learning models for beta thalassemia prediction: an explainable AI approach for smart healthcare 5.0

Abdul Hannan Khan, Asaad Algarni, Raheem Sarwar, Muhammad Bilal Shoaib Khan et al.
Frontiers in Medicine
Hemoglobinopathies and Related Disorders
article

Interpretable machine learning models for beta thalassemia prediction: an explainable AI approach for smart healthcare 5.0

Abdul Hannan Khan, Asaad Algarni, Raheem Sarwar, Muhammad Bilal Shoaib Khan, Anas Bilal, Maria Abbas
article en

Abstract

Furthermore ensuring the models transparency and interpretability, the proposed method integrates SHapley Ad-ditive exPlanations (SHAP) and Local Interpretable Model-Agnostic Explanations (LIME), enabling both global and local interpretability of model predictions. SHAP gives us insight into important features at the global level, while LIME explains individual predictions, making the model's decisions more comprehensible for clinical applications.

Frontiers in MedicineVol. 12
Northern Border University (SA), Manchester Metropolitan University (GB), Hainan Normal University (CN), Green University of Bangladesh (BD), Green Chemistry (PL)
Northern Border University
Openalex Percentile: Top 89%
Hemoglobinopathies and Related Disorders
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Interpretable machine learning models for beta thalassemia prediction: an explainable AI approach for smart healthcare 5.0 — Abdul Hannan Khan, Asaad Algarni, et al. · Frontiers in Medicine (2026) | TGRS Research Map | TGRS