Protein biomarkers associated with left bundle branch block in patients with heart failure and reduced ejection fraction
In HFrEF, LBBB was associated with an altered circulating proteome. FGF2 and EGFR were highly dysregulated between the groups and the MAPK signalling pathway was affected, all of which may be pathophysiologically involved in the accelerated cardiac remodelling observed in these patients. These findings constitute a foundation for future studies of relevant LBBB-related biomarkers, treatment targets, and mechanisms behind the cardiac remodelling observed when LBBB is superimposed on HFrEF.
Authors
- L. H. Lund
- Gianluigi Savarese (ORCID: https://orcid.org/0000-0001-7732-0887)
- Allan Z. Zhao (ORCID: https://orcid.org/0000-0002-2492-0923)
- Eric Rullman (ORCID: https://orcid.org/0000-0003-2854-7262)
- Ulrika Reistam (ORCID: https://orcid.org/0000-0002-9192-8992)
- Frieder Braunschweig (ORCID: https://orcid.org/0000-0002-4966-1315)
- Marcus Ståhlberg (ORCID: https://orcid.org/0000-0003-0319-6240)
- Christian Vestman
- Karin Ljung (ORCID: https://orcid.org/0009-0004-0787-9254)
- A.A. Voors
- Chim C. Lang
Institutions
- University Medical Center Groningen (NL)
- Karolinska University Hospital (SE)
- University of Dundee (GB)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
- National Institutes of Biotechnology Malaysia (MY)
- National University of Malaysia (MY)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1093/eschf/xvag009
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00