Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis
Low-energy fractional CO<sub>2</sub> laser irradiation augments the biological activity of MSC-derived Exos through photothermal stimulation. These Exos, in turn, enhance endothelial cell functions by activating the S1PR1/protein kinase B/hypoxia-inducible factor 1 alpha signaling pathway, ultimately accelerating the repair of diabetic wounds.
Authors
- Zhe Ji (ORCID: https://orcid.org/0000-0002-8532-333X)
- Peisheng Jin (ORCID: https://orcid.org/0000-0002-2239-0156)
- Xiangbin Zhao
- Haonan Wang (ORCID: https://orcid.org/0000-0003-4921-0431)
- Kang Guo
- Tao Li
- Jin-Yuan Chen
- Qiang Li
- Chen-Chen Zhu
- Xue-Yang Li
- Yu-Ting Wang
Institutions
- Xuzhou Medical College (CN)
- Shangqiu First People's Hospital (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
- Cixian People's Hospital (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2026-01-14
- DOI
- https://doi.org/10.4239/wjd.v17.i1.112942
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00