Efficacy of Personalized Connectivity-Guided Accelerated Brain Stimulation in a Naturalistic Treatment-Resistant Depression Population
These findings provide early evidence for the generalizability of connectivity-guided personalized TMS in a naturalistic Asian TRD population with substantial psychiatric comorbidities. TAO-TMS offers a cost-effective alternative to ECT, positioning it as a viable precision psychiatry intervention.
Authors
- Aihuiping Xue (ORCID: https://orcid.org/0009-0008-7907-8594)
- Shih Ee Goh
- Trevor Wei Kiat Tan (ORCID: https://orcid.org/0000-0002-3732-4768)
- Leon Qi Rong Ooi (ORCID: https://orcid.org/0000-0002-3546-4580)
- Hasvinjit Kaur Gulwant Singh
- Jovi Zheng Jie Koh
- Jia Hui Chai
- Rachel Si Yun Tan
- Ru Kong
- B. T. Thomas Yeo
- Xiao Wei Tan
- JonathanJie Lee
- Luming Shi
- Phern-Chern Tor
- Jingwen Cheng
Institutions
- National University of Singapore (SG)
- Institute of Mental Health (IN)
- National University Hospital (SG)
- Institute of Mental Health (RS)
- Singapore Clinical Research Institute (SG)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-13
- DOI
- https://doi.org/10.64898/2026.01.11.26343900
- Primary Topic
- Digital Mental Health Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation Singapore
- Temasek Foundation
- National Institutes of Health
- Medical Research Council
- National Medical Research Council