Melatonin alleviates chronic intermittent hypoxia-induced gastric mucosal injury via attenuation of oxidative stress and JNK-mediated apoptotic signaling in rats
Chronic intermittent hypoxia induces gastric mucosal injury, which is associated with oxidative stress imbalance and activation of JNK-mediated apoptotic signaling. Melatonin exerts a protective effect by enhancing antioxidant capacity and suppressing the JNK-Bax/Bcl-2 pathway.
Authors
- Xiao Song
- Hua Yu (ORCID: https://orcid.org/0000-0002-3087-5911)
- Ji Eun Hong
- Jia F. Luo
- Jia B. Zhang
- Yue D. Li
- Xin H. Yuan
- Xin R. Li
- Huan H. Jiang
- Yanlei Ge
- Cong H. Liu
- Ai S. Fu
- Tie J. Liu
- Cheng X. Nie
Institutions
- North China University of Science and Technology (CN)
- Hospital of Hebei Province (CN)
- North China University of Science and Technology Affiliated Hospital (CN)
- Hebei General Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1371/journal.pone.0338391
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hebei Province
- North China University of Technology