Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization and in vivo experiment
Our study demonstrated that elevated serum levels of IL-12B are associated with an increased risk of GE. The results were validated through <i>in vivo</i> experiments. These results underscore the crucial role of targeted anti-inflammatory therapy in the treatment of epilepsy.
Authors
- Yunyun Lu (ORCID: https://orcid.org/0009-0006-2405-8217)
- Yu Wang
- Feng Chen
- Shuaishuai Wang
- Aijun Feng
- Yan Li
Institutions
- Jiangsu University (CN)
- Anhui Medical University (CN)
- Wuhu Fourth People Hospital (CN)
- Xuzhou Cancer Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fneur.2025.1706857
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China