Drug Rechallenge after Immune Checkpoint Inhibitor-Induced Inflammation and Optic Nerve Disorders
In the majority of cases, ICI-OND occurs bilaterally with painless vision decline and color vision deficits. Cessation of drug along with initiation of systemic steroids can improve vision to 20/40 or better in at least one involved eye, and although we included a smaller subset of patients, we found that ICI can be rechallenged after completion of steroids, without documented recurrence of ICI-OND in most patients.
Authors
- Rebecca Silverman (ORCID: https://orcid.org/0000-0001-6313-1153)
- David H. Abramson (ORCID: https://orcid.org/0000-0002-0118-6391)
- Julia Canestraro (ORCID: https://orcid.org/0000-0002-6548-6879)
- Jasmine H. Francis (ORCID: https://orcid.org/0000-0002-1889-3447)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Wills Eye Hospital (US)
Publication Details
- Journal
- Ocular Oncology and Pathology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1159/000550281
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00