Cerebellar contributions to cognitive deterioration in Parkinson's disease: Insights from multi-omics and longitudinal data
Our study indicates that the effective connectivity threshold from Crus I to the inferior frontal gyrus may predict short-term cognitive decline. These findings highlight the role of the cerebellum in PD-related cognitive decline and may provide important insights for early intervention strategies.
Authors
- Junjie Zheng (ORCID: https://orcid.org/0000-0002-3031-3556)
- Hu Xm
- W. Zhang
- Wei Liu (ORCID: https://orcid.org/0000-0002-7908-8476)
- P. Huang (ORCID: https://orcid.org/0009-0004-1191-4139)
- Yukun Feng
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Nanjing Brain Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Nanjing Jiangning Hospital (CN)
- Hainan Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1016/j.nbd.2026.107275
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00