Deciphering the interplay between inflammation and dysregulated autophagy in lupus nephritis through network analysis and experimental validation
EGFR is a key regulatory factor related to autophagy in LN. The excessive activation of EGFR affects the autophagy of LN podocytes, providing new mechanistic insights and potential therapeutic targets for LN.
Authors
- Xin Lv (ORCID: https://orcid.org/0000-0002-5431-4529)
- Qice Sun (ORCID: https://orcid.org/0000-0002-8963-6528)
- Runrun Zhang (ORCID: https://orcid.org/0000-0002-9948-6332)
- W M Huang
- Ting Zhao
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcell.2026.1764975
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhejiang Chinese Medical University
- Zhejiang Traditional Chinese Medicine Administration
- Natural Science Foundation of Zhejiang Province